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  • Title: Cytotoxic and radiosensitizing effects of 5-thio-D-glucose on hypoxic cells.
    Author: Song CW, Clement JJ, Levitt SH.
    Journal: Radiology; 1977 Apr; 123(1):201-5. PubMed ID: 847150.
    Abstract:
    The effect of 5-thio-D-glucose on the viability and radiosensitivity of P815-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells; moreover, it sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These features, together with its low toxicity, suggest that 5- thio-D-glucose may be useful adjuvant to radiotherapy
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