These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni.
    Author: Badawi AF, Cooper DP, Mostafa MH, Doenhoff MJ, Probert A, Fallon P, Cooper R, O'Connor PJ.
    Journal: Carcinogenesis; 1993 Apr; 14(4):653-7. PubMed ID: 8472329.
    Abstract:
    Male and female BK-TO mice were infected with different numbers of Schistosoma mansoni cercariae under standard environmental conditions. Promutagenic methylation damage (O6-methyldeoxyguanosine; O6-MedG) was detected in liver DNA, but not in kidney, spleen or bladder DNA of infected animals. It was shown that levels of hepatic O6-MedG increased with increasing intensities of schistosomal infection. Possible mechanisms of action are discussed. These include the activating effects of schistosomes and their products on murine macrophages and subsequent endogenous formation of N-nitroso compounds by the activated macrophages.
    [Abstract] [Full Text] [Related] [New Search]