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  • Title: Effects of neurotoxins on brain creatine kinase activity.
    Author: Matsuoka M, Inoue N, Igisu H, Kohriyama K.
    Journal: Environ Res; 1993 Apr; 61(1):37-42. PubMed ID: 8472675.
    Abstract:
    The effects of ethylene oxide (EO), acrylamide, N,N'-methylene-bis-acrylamide (bis-acrylamide), and methyl mercury chloride (MMC) on brain creatine kinase (CK) activity were examined in vivo. EO and acrylamide, both of which cause central-peripheral distal axonopathy, inhibited CK activity in the brain and spinal cord. On the other hand, neither bis-acrylamide, a nonneurotoxic analogue, nor MMC which causes neuronopathy affected brain CK activity significantly. The inhibition of CK may play a role in the pathogenesis of distal axonal degeneration in the central and peripheral nervous systems.
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