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  • Title: Dicyanogold (I) is a common human metabolite of different gold drugs.
    Author: Elder RC, Zhao Z, Zhang Y, Dorsey JG, Hess EV, Tepperman K.
    Journal: J Rheumatol; 1993 Feb; 20(2):268-72. PubMed ID: 8474063.
    Abstract:
    Gold based drugs and their metabolites have been characterized using reversed phase, ion pairing chromatography with an inductively coupled plasma mass spectrometer as an element specific detector. For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood. The same compound is also identified in the urine and blood of a patient taking auranofin and in patients taking solganol. This represents the first identification of a specific gold metabolite in biological fluids taken from patients undergoing gold therapy and the first evidence that different gold drugs have common metabolites.
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