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  • Title: Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain.
    Author: Burt DR, Creese I, Snyder SH.
    Journal: Science; 1977 Apr 15; 196(4287):326-8. PubMed ID: 847477.
    Abstract:
    Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.
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