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  • Title: Time of day of birth and absence of endocrine and uterine contractile activity rhythms in sheep.
    Author: Apostolakis EM, Rice KE, Longo LD, Seron-Ferre M, Yellon SM.
    Journal: Am J Physiol; 1993 Apr; 264(4 Pt 1):E534-40. PubMed ID: 8476031.
    Abstract:
    To determine whether 24-h rhythms characterize hormone secretion and uterine activity in the pregnant sheep, blood samples were drawn every 1-4 h for 48 h from ewes and fetuses from day 120 of gestation to term. Repetitive 24-h rhythms were absent for cortisol, progesterone, and prolactin in maternal and fetal circulation and for hourly mean uterine contraction rate and amplitude. To test whether photoperiod or pineal melatonin contributes to the absence of rhythms, pineal-intact and pinealectomized ewes and their fetuses were studied in reverse photoperiod. Again, there was little evidence to suggest 24-h endocrine rhythms except for prolactin in two fetuses by cosinor analyses. Prolactin concentrations were increased in pinealectomized ewes and their fetuses. In the apparent absence of rhythms, 20 of 21 pineal-intact ewes gave birth at night; however, 6 out of 7 pinealectomized ewes gave birth during the day. Thus photoperiod and the maternal pineal gland profoundly influenced the time of day of birth in the absence of circadian endocrine or uterine activity rhythms.
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