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  • Title: Drug-induced dystonia in a patient with C4 quadriplegia. Case report.
    Author: Reecer MV, Clinchot DM, Tipton DB.
    Journal: Am J Phys Med Rehabil; 1993 Apr; 72(2):97-8. PubMed ID: 8476550.
    Abstract:
    Prochlorperazine, a piperazine phenothiazine, is a commonly used anti-emetic that blocks dopamine receptors in the central nervous system. Prochlorperazine causes various extrapyramidal syndromes, with the incidence in the inpatient population estimated to be 0.5 to 0.8%. These side effects are typically manifested by motor dysfunction and easily observed on physical examination. We report the case of an 18-year-old male with C4 complete quadriplegia who developed an acute dystonic reaction isolated to the tongue during short-term treatment with prochlorperazine. This case demonstrates the importance of maintaining a high level of suspicion in the spinal cord population, considering that many key physical findings may be absent below the level of function.
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