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  • Title: Bronchocentric granulomatosis, acute renal failure, and high titer antineutrophil cytoplasmic antibodies: possible variants of Wegener's granulomatosis.
    Author: Fannin SW, Hagley MT, Seibert JD, Koenig TJ.
    Journal: J Rheumatol; 1993 Mar; 20(3):507-9. PubMed ID: 8478859.
    Abstract:
    We describe 2 patients with clinical syndromes suggestive of Wegener's granulomatosis: elevated titers of cytoplasmic antineutrophil cytoplasmic antibodies (cANCA), bronchocentric granulomatosis, and acute renal failure. A renal biopsy in one case showed crescentic glomerulonephritis and in the other case showed interstitial nephritis. These cases may reflect bronchocentric granulomatosis among a spectrum of diseases associated with cANCA. Use of cANCA may identify those patients with bronchocentric granulomatosis who require immunosuppressive therapy.
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