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  • Title: Morphine inhibits antidromic vasodilatation without affecting the excitability of C-polymodal nociceptors in the skin of the rat.
    Author: Shakhanbeh J, Lynn B.
    Journal: Brain Res; 1993 Apr 02; 607(1-2):314-8. PubMed ID: 8481806.
    Abstract:
    The effect of morphine was examined under identical conditions on (a) antidromic vasodilatation, an 'efferent' function of C-nociceptors in the skin, and (b) afferent responses to heat and pressure of C-polymodal nociceptors. Morphine caused a large, naloxone-reversible, fall in peak antidromic vasodilatation (ADV). However it caused no significant change in heat or mechanical excitability of C-polymodal nociceptors in normal or mildly inflamed skin. The mechanisms by which morphine might affect efferent, but not afferent, functions of C-nociceptors are discussed.
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