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Title: An efficient synthesis of 4 beta- and 6 alpha-hydroxylated bile acids. Author: Yoshimura T, Mahara R, Kurosawa T, Ikegawa S, Tohma M. Journal: Steroids; 1993 Feb; 58(2):52-8. PubMed ID: 8484184. Abstract: An efficient method for the preparation of 4 beta- and 6 alpha-hydroxylated bile acids has been developed. It involved a highly stereoselective acetoxylation at the 4 beta and 6 alpha positions of 3- and 7-oxo bile acids, respectively, with lead tetraacetate in the presence of boron trifluoride etherate in acetic acid. Reduction of the resulting alpha-acetoxy ketones with sodium borohydride or tert-butylamine borane complex, and alkaline hydrolysis, provided the desired bile acids in good yields.[Abstract] [Full Text] [Related] [New Search]