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  • Title: Estrogen receptor immunoreactive neurons in the fetal ferret forebrain.
    Author: Tobet SA, Basham ME, Baum MJ.
    Journal: Brain Res Dev Brain Res; 1993 Apr 16; 72(2):167-80. PubMed ID: 8485841.
    Abstract:
    The development of estrogen receptors was studied in the preoptic area/anterior hypothalamus (POA/AH) of fetal male and female ferrets. In males this region includes a nucleus (MN-POA/AH), delineated by Nissl stains, which is not discernible in females. The results reveal the distribution of estrogen receptor containing cells during the period when estrogen is known to induce the differentiation of the male ferret's MN-POA/AH. Brains were taken from ferret kits on days 30, 34, 37 and 40 of a 41-42 day gestation, and were processed utilizing the H222 monoclonal antibody to reveal estrogen receptors. At E30 there were numerous H222 immunoreactive (ir) cells in central regions of the POA/AH. From E30 to E40 there was a striking increase in the number of H222ir cells in the POA/AH. A broad sweep of H222ir cells extended from the ventral POA dorsally and laterally into the caudal POA and AH of both males and females. H222ir cells were not restricted to the region of the MN-POA/AH at any fetal age. H222 immunoreaction product at E30 was restricted to nuclear compartments. By E40, H222ir processes extended from some cells with H222ir nuclei in the medial and lateral POA/AH in both males and females. At the older fetal ages immunopositive cell numbers increased in lateral positions. At E34 and E37 (but not E30) selective ventricular zones, and regions between the hypothalamus and amygdala contained H222ir cells, suggesting the presence of estrogen receptors in cells during migration. Although the amygdala contained a few H222ir cells as early as E34, the cortex lacked H222ir cells even as late as E40. The appearance of H222ir cells in positions suggestive of migration is consistent with the hypothesis that estrogen receptors play some role in determining cell positions in certain regions of the developing nervous system.
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