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  • Title: Effect of cyclosporin A and its metabolites and analogs on lipid peroxidation in rabbit renal microsomes.
    Author: Sadeg N, Pham Huy C, Martin C, Warnet JM, Claude JR.
    Journal: Drug Chem Toxicol; 1993; 16(2):165-74. PubMed ID: 8486097.
    Abstract:
    Rabbit renal microsomes were used to investigate the effect on lipid peroxidation (LPO) of cyclosporin A (CsA) and its first generation metabolites M1, M17 and M21, and of two natural CsA analogs: cyclosporins C and D (CsC & CsD respectively), at concentrations of 1 to 10 micrograms/ml. No induction of lipid peroxidation was observed with these substances except CsA at a high level (10 microgram/ml); but at a concentration of CsA that would be reached in vivo, no inductive effect on LPO was noted. A moderate inhibitory effect upon LPO was observed with CsC and M21, but its biological significance is questionable.
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