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  • Title: [Ocular complications of long-term survival of bone marrow transplantation. A prospective study with 21 patients].
    Author: Bautista Juanes JA, Theischen M, Beelen DW, Pauleikhoff D, Koch JM, Waubke TN, Wessing A.
    Journal: Klin Monbl Augenheilkd; 1993 Feb; 202(2):110-5. PubMed ID: 8487463.
    Abstract:
    BACKGROUND: Survival time after bone marrow transplantation is getting increasingly longer and secondary ocular complications need to be identified and deserve more attention as so far. PATIENTS AND METHODS: We evaluated the ocular complications of 21 not selected, long-term survivors after bone marrow transplantation in a prospective study. The ophthalmological examination consisted of visual acuity, slit lamp examination, tonometry and ophthalmoscopy. It included also determination of tears break-up-time, Jones-test, rose bengal staining and impression cytology of the conjunctiva. RESULTS: The major ocular complication was the development of a keratoconjunctivitis sicca syndrome in 14 of the 21 patients. This complication is probably due to the total-body irradiation in the preparative before and to the development of a chronic Graft-versus-Host-Disease after transplantation. 13 of the 21 patients developed a cataract. This might be a result of the total-body irradiation and a prolonged high steroid intake. CONCLUSION: The frequency and severity of ocular complications suggest that detailed ocular examinations should be performed routinely in patients after bone marrow transplantation.
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