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  • Title: [The formation of T-suppressors that suppress the activity of alloreactive T-cells after lymphocyte interaction with 2 different thymus-derived mediators].
    Author: Anfalova TV, Lutsan NI.
    Journal: Ontogenez; 1993; 24(2):76-82. PubMed ID: 8488015.
    Abstract:
    The data are presented on simultaneous interaction of thymocytes and T-cells from lymph nodes with two humoral factors produced by macrophages and epithelial cells, main stromal elements of the thymus. Such contact of T-cells with two mediators resulted in the formation of T-suppressors capable of inhibiting the activity of syngeneic allospecific T-lymphocytes. These T-suppressors did not alter the response to another antigen but inhibited proliferation of donor cells. Involvement of such mechanism of T-suppressor formation in regulation of the immune status is discussed.
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