These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: [Hematologic response to low dose natural interferon-alpha in a case of CML with myelo-megakaryoblastic crisis].
    Author: Nozaki H, Usui T, Yamauchi K, Kobayashi N, Nakamura Y, Watanabe K, Nagao T, Arimori S.
    Journal: Rinsho Ketsueki; 1993 Feb; 34(2):232-4. PubMed ID: 8492424.
    Abstract:
    A 59-year-old female with splenomegaly was admitted in November, 1989. Her WBC was 7,900/microliters with 51% myeloblasts and 10% megakaryoblasts. Analysis of the surface markers showed that 56.5% were CD13 positive and 66.8% carried platelet GpIIb/IIIa. The Ph1 chromosome was 100% positive. VPM therapy was started but proved ineffective, as was subsequent MCNU therapy. The patient was given intramuscular human lymphoblastoid interferon-alpha (1.2 million IU daily) for more than 20 months. She had improved to the accelerated phase after INF-alpha therapy for 13 months. Thus there appears to be a relationship between INF-alpha and myelo-megakaryoblastic crisis.
    [Abstract] [Full Text] [Related] [New Search]