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  • Title: [Inflammatory role of eosinophil in allergic reactions].
    Author: Kimura I, Takahashi K.
    Journal: Nihon Rinsho; 1993 Mar; 51(3):651-6. PubMed ID: 8492439.
    Abstract:
    A role of eosinophil is thought to be an inflammatory effect, although it had been believed that the cell has a protective role by blocking mediators from the mast cell. Eosinophils release several kinds of basic and cationic proteins following receptor-mediated activation. These mediators gradually lead to tissue damage of the bronchi, skin, nerve, heart and other general organs. Bronchial asthma and eosinophilic pneumonia as well as hyper-eosinophilic syndrome is based on this pathogenesis. Potent therapy, including steroids, will be needed for long terms in these diseases with tissue eosinophilia.
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