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  • Title: Rapid toxicological screening of barbiturates in plasma by wide-bore capillary gas chromatography and nitrogen-phosphorus detection.
    Author: Coudoré F, Alazard JM, Paire M, Andraud G, Lavarenne J.
    Journal: J Anal Toxicol; 1993; 17(2):109-13. PubMed ID: 8492562.
    Abstract:
    A rapid screening technique for the identification and quantitation of some barbiturates in plasma is reported. The method employs a one-step extraction at pH 5.8 into an organic phase, separation of compounds by gas chromatography with a wide-bore (0.75-mm i.d.) fused-silica capillary column connected to a direct injection kit, and nitrogen-phosphorus detection. Identification of each barbiturate is by retention time relative to brallobarbital, confirmed using another wide-bore column of slightly different polarity, connected to a flame-ionization detector. Rapid quantitation may be obtained with extracted standards used for drug screening. Detection threshold (0.5 micrograms/mL in a 0.5-mL serum sample and 0.5-microL injection volume), precision (CV < or = 11%), and linearity (r > 0.99) were satisfactory for routine toxicological applications.
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