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  • Title: Uncoupling of mitochondrial respiration by ADP.
    Author: Out TA, Krab K, Kemp A, Slater EC.
    Journal: Biochim Biophys Acta; 1977 Mar 11; 459(3):612-6. PubMed ID: 849439.
    Abstract:
    Even when oxidative phosphorylation is blocked completely by addition of high concentrations of oligomycin plus aurovertin, the addition of ADP to a suspension of mitochondria containing a high concentration of ATP inside the mitochondria induces a stimulation of respiration and oxidation of nicotinamide nucleotide. It is concluded that transport of ADP into mitochondria with a high endogenous ATP/ADP ratio requires energy.
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