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  • Title: Ciprofloxacin-induced nephrotoxicity in patients with cancer.
    Author: Lo WK, Rolston KV, Rubenstein EB, Bodey GP.
    Journal: Arch Intern Med; 1993 May 24; 153(10):1258-62. PubMed ID: 8494478.
    Abstract:
    Nephrotoxicity associated with ciprofloxacin is uncommon. Five patients with cancer who developed acute renal failure that followed treatment with ciprofloxacin are described and an additional 15 cases reported in the literature are reviewed. Other than elevation of serum creatinine levels, characteristic clinical manifestations and abnormal laboratory findings are not frequently present. Allergic interstitial nephritis is believed to be the underlying pathological-process. Definitive diagnosis requires performance of renal biopsy, although this is not always feasible. An improvement in renal function that followed the discontinuation of the offending antibiotic supports the presumptive diagnosis of ciprofloxacin-induced acute renal failure.
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