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  • Title: HLA-DRB1 gene sequences in HLA-DR4 positive and negative patients with rheumatoid arthritis.
    Author: Becking A, Pluschke G, Krawinkel U, Melchers I, Peter HH, Lang B.
    Journal: Eur J Immunogenet; 1993 Apr; 20(2):83-9. PubMed ID: 8494871.
    Abstract:
    The second exon of the DRB1 gene encoding for the first domain of the HLA-DR beta 1-chain was sequenced in 16 patients (10 DR4/DR1 positive, 6 DR4/DR1 negative) with seropositive rheumatoid arthritis (RA). We could confirm the strong association of susceptibility to RA with functionally equivalent conformations on otherwise distinct MHC molecules. At least one HLA-DR allele in all of the analysed DR4 or DR1 positive patients showed such an epitope with a minimal variability limited to residue 71. However, in HLA-DR4 and -DR1 negative patients such a similar epitope could not be detected.
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