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  • Title: Determination of fluoxetine and norfluoxetine in human plasma by capillary gas chromatography with electron-capture detection.
    Author: Lantz RJ, Farid KZ, Koons J, Tenbarge JB, Bopp RJ.
    Journal: J Chromatogr; 1993 Apr 21; 614(1):175-9. PubMed ID: 8496280.
    Abstract:
    A capillary gas chromatographic method with 63Ni electron-capture detection is reported for the determination of fluoxetine (Prozac) and its metabolite norfluoxetine in human plasma. A liquid-liquid extraction is used, followed by derivatization with heptafluorobutyric anhydride to increase the sensitivity of detection. A 30 m x 0.25 mm I.D. DB-17 capillary column resolves the compounds from endogenous matrix interferences. The limit of quantitation by this method is 5 ng/ml for each compound. Stability studies show that fluoxetine and norfluoxetine are stable in human plasma for up to 96 h at room temperature and up to one year at -20 degrees C.
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