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  • Title: T cell activation and cytokine release in streptococcal toxic shock-like syndrome.
    Author: Nadal D, Lauener RP, Braegger CP, Kaufhold A, Simma B, Lütticken R, Seger RA.
    Journal: J Pediatr; 1993 May; 122(5 Pt 1):727-9. PubMed ID: 8496751.
    Abstract:
    A 5-year-old girl with streptococcal toxic shock-like syndrome during varicella infection had high levels of tumor necrosis factor alpha and interleukin-6 but no interleukin-1 or interleukin-2 in the serum. Intravenous administration of gamma-globulin coincided with clinical improvement and with reduction of the levels of tumor necrosis factor alpha and interleukin-6. The data suggest that streptococcal pyrogenic exotoxins trigger synthesis of tumor necrosis factor alpha and interleukin-6 in vivo; intravenously administered gamma-globulin may down-regulate the cytokine response.
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