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  • Title: Effects of sevoflurane, isoflurane, and halothane on mechanical and electrophysiologic properties of canine myocardium.
    Author: Hatakeyama N, Ito Y, Momose Y.
    Journal: Anesth Analg; 1993 Jun; 76(6):1327-32. PubMed ID: 8498673.
    Abstract:
    We studied the effects of sevoflurane on contraction and membrane potentials in isolated canine ventricular muscle strips. Sevoflurane (> 0.5%) depressed electrically induced contraction in a dose-dependent manner. Moreover, sevoflurane did not show stimulation frequency-dependent depression in contraction as shown with local anesthetics. The inhibitory effect was more pronounced in high-K+ Tyrode's solution than in normal Tyrode's solution, suggesting that sevoflurane may inhibit transmembrane Ca2+ influx. In contrast, isoflurane and halothane were equally effective in depressing electrically induced contractions in normal and high-K+ Tyrode's solution. In electrophysiologic experiments, sevoflurane at higher concentrations (> 2.0%) depressed both overshoot and the plateau phase of the action potentials. These depressant effects were more pronounced in high-K+ Tyrode's solution. Resting membrane potential was not affected by sevoflurane. We conclude that depression of myocardial contractility by sevoflurane may be due to a block of the transmembrane calcium influx.
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