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  • Title: Detection of Toxoplasma gondii antigen-containing immune complexes in the serum of cats.
    Author: Lappin MR, Cayatte S, Powell CC, Gigliotti A, Cooper C, Roberts SM.
    Journal: Am J Vet Res; 1993 Mar; 54(3):415-9. PubMed ID: 8498745.
    Abstract:
    Enzyme-linked immunosorbent assays for the detection of Toxoplasma gondii antigen-containing IgM immune complexes (T gondii-specific IgM-IC) and IgG immune complexes (T gondii-specific IgG-IC) in the serum of cats were developed. Serum from clinically ill, naturally infected cats; healthy, naturally infected cats; and healthy cats experimentally inoculated with T gondii was assayed. All combinations of T gondii-specific IgM, IgG, antigens, IgM-IC, and IgG-IC were detected in naturally infected and experimentally infected cats. Clinically ill cats and cats with ocular signs of toxoplasmosis were more likely than healthy cats to have T gondii-specific IC in serum. It was concluded that T gondii-specific IC form in the serum of cats, may play a role in clinical disease development, and affect the results of T gondii-specific IgM, IgG, and antigen serologic assays.
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