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  • Title: High-frequency monitoring for early detection of cisplatin ototoxicity.
    Author: Fausti SA, Henry JA, Schaffer HI, Olson DJ, Frey RH, Bagby GC.
    Journal: Arch Otolaryngol Head Neck Surg; 1993 Jun; 119(6):661-6. PubMed ID: 8499098.
    Abstract:
    Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial conventional (0.25 to 8 kHz) and high-frequency (> or = 8 kHz) threshold monitoring was performed in patients receiving cisplatin, resulting in 84% of ears showing hearing loss, of which 71% were detected first in frequencies of 8 kHz or greater. By analysis according to an individualized, specific high-frequency range, early identification of hearing loss occurred in 94% of ears showing change. This five-frequency procedure is a sensitive detector of ototoxicity and is proposed as an alternative monitoring protocol for patients receiving cisplatin who cannot tolerate extended testing.
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