These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of a hypercholesterolaemia-inducing diet on biliary electrolytes and lipid secretion in the rat.
    Author: Monte MJ, Jimenez R.
    Journal: Int J Exp Pathol; 1993 Apr; 74(2):203-10. PubMed ID: 8499321.
    Abstract:
    The effects of a high cholesterol/cholate diet on the biliary secretion of bile acids, cholesterol, phospholipid and inorganic electrolytes in the rat were examined. Wistar rats were fed a hypercholesterolaemia-inducing diet (HID) for 20 days prior to the biliary experiments. Rats fed a standard laboratory diet were used as controls. The HID diet increased plasma cholesterol concentrations and the hepatic content of total, free and esterified cholesterol, without changes in ALP*, ALT and AST plasma activities. Bile flow and biliary secretion of bile acids and inorganic electrolytes were markedly increased in the hypercholesterolaemic animals. The stimulated biliary secretion was due to an increase in both the bile acid-dependent and bile acid-independent fractions of bile flow. An increase in the bile acid pool induced by the administration of exogenous cholic acid/cholesterol would account for these changes in bile flow and inorganic electrolyte secretion. Nevertheless, the increase in the bile acid-independent bile flow could be also related, at least to some extent, to a higher efficiency of bicarbonate transport into bile. The HID diet also increased both cholesterol and phospholipid biliary outputs, whereas it did not modify the relationship between lipid and bile acid secretion. The lithogenic index of bile was reduced in the rats after the HID regimen due to a relatively higher increase in the biliary outputs of phospholipids and bile acids than of cholesterol.
    [Abstract] [Full Text] [Related] [New Search]