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  • Title: Pradimicins T1 and T2, new antifungal antibiotics produced by an actinomycete. II. Structures and biosynthesis.
    Author: Hasegawa T, Kakushima M, Hatori M, Aburaki S, Kakinuma S, Furumai T, Oki T.
    Journal: J Antibiot (Tokyo); 1993 Apr; 46(4):598-605. PubMed ID: 8501002.
    Abstract:
    Pradimicins T1 and T2 are new members of the pradimicin family of antibiotics produced by an actinomycete strain AA3798. Pradimicins T1 and T2 are dihydrobenzo[a]naphthacenequinones substituted with 3 and 2 sugar moieties, respectively. The salient feature in their structures is an L-xylose attached to the phenolic hydroxyl group at C-11. Bioconversion experiments using a blocked mutant B-54 of strain AA3798 not only explored a plausible biosynthetic pathway of pradimicins T1 and T2, but also provided evidence of 5S,6S configuration.
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