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  • Title: [The effect of the gas hypoxic mixture GHM-8 on the capacity of the stromal clonogenic cells (CFU-F) in rat bone marrow for postradiation recovery].
    Author: Konopliannikov AG, Waĭnson AA, Kolesnikova AI, Zaĭtsev VA, Kal'sina SSh, Lepekhina LA.
    Journal: Radiobiologiia; 1993; 33(2):244-54. PubMed ID: 8502742.
    Abstract:
    The effect of gas hypoxic mixture, containing 8% of O2 (GHM-8), on the ability of cell precursors of haemopoietic stroma (which form colonies (clones) of fibroblasts (CFU-F) in a culture, and are present in the bone marrow of adult rats) to repair potentially lethal and sublethal radiation damages has been investigated. The recovery of CFU-F from potentially lethal damages, that was studied after their delayed survival in a culture following irradiation of animals, proceeds at nearly the same rate in cells irradiated both in the air and in hypoxic conditions (GHM-8). Fractionated irradiation reduces the radioprotective effect of GHM-8 for CFU-F, particularly for the radioresistant subpopulation; the ability of CFU-F to recover from sublethal radiation damages decreases.
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