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  • Title: [Effects of stimulation of SI cortex and cerebral peduncle on the nociceptive responses of spinal dorsal horn neurons in the rat].
    Author: Yuan B, Wang GX, Pang TC, Liu XL.
    Journal: Sheng Li Xue Bao; 1993 Feb; 45(1):26-35. PubMed ID: 8503029.
    Abstract:
    Single spinal dorsal horn neurons were recorded extracellularly with glass micropipettes, and the effect of stimulation of SI cortex or cerebral peduncle (CP) was observed on the long latency discharges (C-fiber evoked response) of the wide dynamic range (WDR) neurons induced by intense electrical skin stimulation. Inhibition was the predominant effect of SI cortex stimulation on the C-fiber evoked responses of WDR neurons. The effect of CP stimulation was similar to that of SI cortex stimulation, except that the former was much more effective than the latter. The inhibition lasted a period of time varying from 400 ms to more than 10 min after CP stimulation in different neurons. Systemic naloxone had no significant effect on the inhibition produced by CP stimulation. Systemic methysergide reduced or eliminated the inhibition in a part of the neurons tested, suggesting that 5-HT, but not opioid peptides, is involved partially in mediation of the descending inhibitory effect originating from the cortex.
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