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  • Title: Lymphangiosarcoma of arm after chronic lymphedema: a rare long-term complication after radical mastectomy in breast cancer patients. Case report and overview.
    Author: Kiricuta IC, Dämmrich J.
    Journal: Strahlenther Onkol; 1993 May; 169(5):291-5. PubMed ID: 8503088.
    Abstract:
    Lymphangiosarcoma after mastectomy was first described by Stewart and Treves in 1948. Today, this tumor associated with chronic lymphedema has become a rare entity, due to less radical surgery. Chronic lymphedema and lymphangiectasia of limbs preceding lymphangiosarcoma may not only be induced by radical mastectomy. Also post-traumatic, congenital, filarial-associated or spontaneous chronic lymphedema may be associated with lymphangiosarcoma. A time interval of years seems to be required before malignant changes supervene and lymphangiosarcoma develops. This paper describes a case with lethal and arising in an edematous arm years after radical mastectomy and irradiation. Current concepts of etiology, histopathology, immunohistology, diagnostic investigation, treatment and prognosis are presented.
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