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  • Title: [Use of buserelin in a fertilization in vitro-embryo transfer program and determination of steroid concentrations of preovulatory follicular fluid].
    Author: Zhuang GL.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1993 Jan; 28(1):10-3, 59. PubMed ID: 8504701.
    Abstract:
    Eleven infertility patients, stimulated by Buserelin/hMG/hCG protocol (BHh group) for superovulation, were compared with thirteen patients using CC/hMG/hCG protocol (CHh group) in an IVF-ET program. The rates of oocyte retrieval, fertilization and cleavage in BHh group were significantly, higher than those in CHh group. Furthermore, the incidence of premature LH surge in BHh group was 0% and 23.1% in CHh group. Eventually there were four pregnancies in BHh group and only one in CHh group. The mean concentrations of estradiol (E2), progesterone (P) and P/E2 ratio in follicular fluid (FF) in BHh group were significantly lower than that in CHh group. The values of FF P/E2 ratio in the range of 10-50 were positively correlated with oocyte fertilization rates. These data suggested that the addition of Buserelin in the superovulation protocol improved the outcome of IVF-ET treatment.
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