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  • Title: Calvasculin, as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene.
    Author: Watanabe Y, Usada N, Minami H, Morita T, Tsugane S, Ishikawa R, Kohama K, Tomida Y, Hidaka H.
    Journal: FEBS Lett; 1993 Jun 07; 324(1):51-5. PubMed ID: 8504859.
    Abstract:
    Cell transformations accompany alterations in cell morphology and microfilament patterns. Calvasculin encodes mRNA termed pEL-98, 18A2, 42A, p9Ka, or mts1, found to be elevated in several metastatic cell lines. We report the elevation of calvasculin expression in SR-3Y1 cells, which show disappearance of ordered microfilaments, compared to that in 3Y1 cells and that the similar distribution of calvasculin to that of actin filaments. Interestingly, calvasculin co-sediments with F-actin and bundles actin filaments in a Ca(2+)-dependent manner. This activity, along with the elevation of calvasculin following transformation, suggests that the disorganization of filaments in SR-3Y1 cell is due to the cross-linking activity of calvasculin.
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