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  • Title: Effects on hypothalamic and telencephalic NE and 5-HT of tegmental knife cuts that produce hyperphagia or hyperdipsia in the rat.
    Author: Grossman SP, Grossman L, Halaris A.
    Journal: Pharmacol Biochem Behav; 1977 Jan; 6(1):101-6. PubMed ID: 850684.
    Abstract:
    Knife cuts in the coronal plane through various aspects of the midbrain tegmentum produced hyperphagia, hyperdipsia, or no effect on ingestive behavior. All of the cuts significantly depleted NE and 5-HT from hypothalamus and forebrain. The brains of hyperphagic or hyperdipsic animals did not differ from those of normophagic and normodipsic animals with respect to hypothalamic NE or 5-HT or telencephalic NE. Both hyperphagic and hyperdipsic animals had significantly lower concentrations of 5-HT in forebrain than rats which sustained similar cuts in the tegmentum which did not affect ingestive behavior.
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