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  • Title: Myasthenic immunoglobulin accelerates acetylcholine receptor degradation.
    Author: Kao I, Drachman DB.
    Journal: Science; 1977 Apr 29; 196(4289):527-9. PubMed ID: 850793.
    Abstract:
    Degradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined from the release of 125I from bound 125I-labeled alpha-bungarotoxin. Addition of immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the degradation rate to a mean of 8.51 +/- 0.44 percent per hour, compared with the mean control rate of 3.97 +/- 0.14 percent per hour (P less than .001). A similar mechanism may possibly be involved in the autoimmune pathogenesis of myasthenia gravis in man.
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