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  • Title: Prognostic factors in telecobalt therapy for early supraglottic carcinoma.
    Author: Inoue T, Matayoshi Y, Inoue T, Ikeda H, Teshima T, Murayama S.
    Journal: Cancer; 1993 Jul 01; 72(1):57-61. PubMed ID: 8508430.
    Abstract:
    BACKGROUND: The local control rates of T1 and T2 supraglottic carcinoma treated with radiation alone were reported as 71% to 92% and 59% to 83%, respectively. The factors that affect the local control rate for early supraglottic carcinoma were investigated. METHODS: From 1967 through 1985, 100 cases with early supraglottic carcinoma (T1N0, 51; T2N0, 49) were treated with telecobalt therapy at the Department of Radiology, Osaka University Hospital. RESULTS: The 5-year actuarial survival rates of cases with T1 and T2 were 69% and 74%, respectively. The 5-year local control rates of cases with T1 and T2 were 77% and 62%, respectively. The local control rate for the epilarynx (94%) was significantly better than that for the lower supraglottis (66%; P < 0.05). For the lower supraglottis, the local control rates of 24 tumors that disappeared at 40 Gy and 58 tumors that persisted at 40 Gy were 88% and 55%, respectively (P < 0.05). CONCLUSIONS: The tumor site was an important prognostic factor in radiation therapy for the supraglottis, as was the tumor response at 40 Gy for the lower supraglottis.
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