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  • Title: Insulin-like effects of bis-glycinato oxovanadium (IV) complex on experimental diabetic rats.
    Author: Nandhini D, Maneemegalai S, Elangovan V, Sekar N, Govindasamy S.
    Journal: Indian J Biochem Biophys; 1993 Feb; 30(1):73-6. PubMed ID: 8509129.
    Abstract:
    The insulin-like activity of bis-glycinato oxovanadium (IV) complex on experimental diabetes has been studied. Rats made diabetic with streptozotocin, after one month, were fed ad libitum with bis-glycinato oxovanadium (IV) complex (30 mg/100 ml) for fifteen days. The altered blood glucose, urea, cholesterol, triglycerides, liver glycogen and the activities of liver enzymes such as hexokinase, lactate dehydrogenase and fructose-1, 6-bisphosphatase, were reverted to normal levels in bis-glycinato oxovanadium (IV) complex treated diabetic rats, thereby suggesting for the insulin-mimetic effect of bis-glycinato oxovanadium (IV) in experimental diabetes.
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