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  • Title: The association of HLA antigens A3, B7, and DW2 with 330 multiple sclerosis patients in the United States.
    Author: Opelz G, Terasaki P, Myers L, Ellison G, Ebers G, Zabriskie J, Weiner H, Kempe H, Sibley W.
    Journal: Tissue Antigens; 1977 Jan; 9(1):54-8. PubMed ID: 850918.
    Abstract:
    Reported associations of HLA antigens with MS have varied considerably. In this study we have examined 330 clinically definite MS patients from the United States. The frequency of DW2 (52%) was highly statistically significant in MS patients as compared to controls (p less than 0.00001). Neither A3 nor B7 was significantly increased in MS; however, the joint occurrences of A3-DW2 (20% vs 7%, p less than 0.001) and B7-DW2 (30% vs 13%, p less than 0.0002) are highly associated with MS.
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