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  • Title: Strain-dependent escape deficit in two rat models of learned helplessness.
    Author: Zhukov DA.
    Journal: Physiol Behav; 1993 May; 53(5):905-9. PubMed ID: 8511206.
    Abstract:
    The shuttle box escape deficit produced by prior inescapable shock (IS) or by escapable shock (ES) was investigated in Koltushi high- (KHA) and low-avoidance (KLA) rat strains, genetically selected on the basis of divergent acquisition of a conditioned avoidance response in a two-way shuttle box. IS enhanced escape failures only in KHA rats. In contrast, ES produce escape deficit only in KLA rats. These data suggest that the learned helplessness interpretation of escape deficit might be relevant only when IS is administered to KHA rats. In the case of KLA rats exposed to ES, escape deficit represents a coping behavior.
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