These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sensitivity of Plasmodium falciparum to chloroquine in pregnant women in Zaria, northern Nigeria.
    Author: Okoyeh JN, Lege-Oguntoye L, Emembolu JO, Sarki U, Slotboom AB.
    Journal: Trop Geogr Med; 1993; 45(2):56-8. PubMed ID: 8511811.
    Abstract:
    Thirty-five pregnant women with Plasmodium falciparum parasitaemia were treated with chloroquine 25 mg/kg body weight over 3 days. They were followed up in vivo by use of a modified 14-day WHO extended field test. In vitro sensitivity of the parasite isolates to chloroquine was assessed by using the WHO microtest method. All pregnant women were aparasitaemic by day 7 and there was no parasite reappearance throughout the 14-day observation period. The mean parasite clearance time (MPCT) was 3.2 +/- 1.4 days. Eleven parasite isolates obtained from the women were highly susceptible to chloroquine in vitro. The effective drug concentration that gave 99% parasite growth inhibition (EC 99) was 0.36 mumol/l.
    [Abstract] [Full Text] [Related] [New Search]