These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Nephron filtration rate in conscious rats recovering from anesthesia.
    Author: Bonvalet JP, Champion M, Wanstok F, Berjal G.
    Journal: Am J Physiol; 1977 Apr; 232(4):F329-34. PubMed ID: 851191.
    Abstract:
    Single-nephron glomerular filtration rate (SNGFR) of superficial (S) and juxtamedullary (JM) nephrons was measured in conscious rats with a [14C]ferrocyanide infusion technique. Experiments were carried out in nondiuretic (ND), salt-loaded (SL), and hemorrhagic hypotensive (HH) rats. Mean SNGFR values of S and JM nephrons were 48.7 +/- 4.5 SE and 61.7 +/- 4.2 in ND, 73.6 +/- 8.7 and 87.5 +/- 10.8 in SL, and 29.9 +/- 5.9 and 36.4 +/- 7.1 in HH rats. These values are higher than the values reported in anesthetized rats. The S-to-JM SNGFR ratio was not significantly different in the three experimental conditions (ND, 0.788 +/- 0.032; SL, 0.843 +/- 0.018; and HH, 0.824 +/- 0.030), and did not differ from the values reported in anesthetized rats in similar experimental conditions. It is concluded that anesthesia exerts a depressive effect on GFR, but does not modify intrarenal SNGFR distribution. Neither saline loading nor hemorrhagic hypotension induces SNGFR intrarenal redistribution in conscious rats.
    [Abstract] [Full Text] [Related] [New Search]