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Title: Neuroactive peptides exist in the midbrain dopaminergic neurons that contain calbindin-D28k. Author: German DC, Liang CL. Journal: Neuroreport; 1993 May; 4(5):491-4. PubMed ID: 8513124. Abstract: Calbindin-D28k, a calcium-binding protein, has been identified within a subpopulation of midbrain dopaminergic (DA) neurons in rats, monkeys and humans. The neuroactive peptides CCK and neurotensin also have been found in a subpopulation of midbrain DA neurons. Using double- and triple-labeling immunocytochemical staining procedures in the rat, we now report that the midbrain DA neurons that contain the peptides also contain calbindin-D28k. Calbindin-D28k may play a role in the co-release of neuroactive peptides with dopamine from the midbrain DA neurons.[Abstract] [Full Text] [Related] [New Search]