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  • Title: [Influence of a series of substances from the group of chlorine-derivative hydrocarbons on the composition of a population of rat liver hepatocytes].
    Author: Beliaeva NN, Bonashevskaia TI, Marshak TL, Brodskiĭ VIa.
    Journal: Biull Eksp Biol Med; 1977 Mar; 83(3):345-8. PubMed ID: 851638.
    Abstract:
    The cytophotometric and kariometric study of the liver hepatocytes in albino rats inhalationally exposed to dichlor- and trichlorpropan showed the latter to be more toxic than the former by its effect on the polyploidization of hepatocyte nuclei. The development of polyploidization was determined by the concentration level of the active agent and the length of exposure to it: the lower the concentration--the more time was required for the realization of the effect.
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