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  • Title: mdr 1 gene-expression and villin synthesis in a colon cancer cell line differentiated by sodium butyrate.
    Author: Petit JM, Chauffert B, Dimanche-Boitrel MT, Genne P, Duchamp O, Martin F.
    Journal: Anticancer Res; 1993; 13(2):487-90. PubMed ID: 8517666.
    Abstract:
    Sodium butyrate (NaBu) but not dimethylsulfoxide (DMSO) induced the synthesis of villin, a protein of the brush border microvilli cytoskeleton, in a rat colon cancer cell line. Neither NaBu nor DMSO altered mdr 1-mRNA expression or multidrug resistance (MDR)--associated cellular transport of doxorubicin. These results show that mdr 1 gene expression and activity are independent of other brush border proteins induced by differentiating agents at the apical pole of the epithelial cell.
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