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  • Title: Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.
    Author: Rocca M, Capelli S, Fini M, Maltarello MC, Veronese FM, Caliceti P, Giardino R.
    Journal: Boll Soc Ital Biol Sper; 1995; 71(5-6):125-32. PubMed ID: 8519486.
    Abstract:
    The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.
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