These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Localization of GW-39 human tumors in hamsters by affinity-purified antibody to carcinoembryonic antigen.
    Author: Primus FJ, Macdonald R, Goldenberg DM, Hansen HJ.
    Journal: Cancer Res; 1977 May; 37(5):1544-7. PubMed ID: 851962.
    Abstract:
    With the paired-labeled antibody technique, the in vivo localization of radioiodinate, affinity-purified antibody to carcinoembryonic antigen (CEA) was studied in GW-39, a xenografted, CEA-producing tumor model. When compared to the whole immunoglobulin G fraction, a 4-fold greater tumor accumulation of radioantibody was obtained with affinity-purified specific CEA antibody. The degree of increased tumor localization of affinity-purified antibody was similar to its improved immunoreactivity as observed in radioimmunoassay and binding to CEA immunoadsorbent. Affinity-purified antibody cross-reactive with CEA and colon carcinoma antigen III was as equally effective in tumor localization as was specific CEA antibody prepared similarly. It thus appears that affinity-purified CEA radioantibody will provide a superior tumor-imaging agent for clinical use.
    [Abstract] [Full Text] [Related] [New Search]