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  • Title: Inhibition of pig kidney diamine oxidase by nazlinin and nazlinin derivatives.
    Author: Cheng E, Dekker HL, van Gelder BF, Koomen GJ.
    Journal: Biochim Biophys Acta; 1995 Dec 06; 1253(2):189-92. PubMed ID: 8519801.
    Abstract:
    Nazlinin (1-(4-butylamino)-1,2,3,4-tetrahydro-beta-carboline) (1), an alkaloid recently isolated from Nitraria schoberi, and its two derivatives, 1-(4-butylamino)-3,4-dihydro-beta-carboline (2) and 1-(4-butylamino)-beta-carboline (3), were synthesized and their interaction with pig kidney diamine oxidase (PKDO) was studied. Nazlinin appeared to be a very poor substrate while 3 was a good substrate with an apparent Km of 9.3-10(-5) M. The enzyme was inhibited by 1 and 2. With both compounds the mode of inhibition found was non-competitive and inhibition constants calculated from the slopes and intercepts of double-reciprocal plots show that 2 is a much more potent inhibitor than the natural product. The relationship between the structure of these compounds and the results found is discussed.
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