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  • Title: A Japanese case of the fibrillar type of dermatitis herpetiformis.
    Author: Shimizu K, Hashimoto T, Fukuda T, Watanabe K, Ishiko A, Niizeki H, Shimizu H, Zone JJ, Nishikawa T.
    Journal: Dermatology; 1995; 191(2):88-92. PubMed ID: 8520073.
    Abstract:
    BACKGROUND: Although dermatitis herpetiformis (DH) is a relatively common disease in Caucasian populations, this disease is very rare in Asian populations including the Japanese. METHODS AND RESULTS: We present a Japanese DH patient, who showed a fibrillar pattern of deposition of IgA, IgG, IgM and C3. The HLA typing revealed no B8/DR3. The survey of the Japanese literature and the comparison to studies on American or European DH revealed several interesting differences: high frequency of the fibrillar pattern, relatively high incidence of deposits of immunoglobulins other than IgA, rarity of gluten-sensitive enteropathy and HLA-B8/DR3 in Japanese DH. CONCLUSION: The present study suggests that there may be a significant difference in pathophysiology between Caucasian and Japanese DH patients.
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