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  • Title: Localization of the CDKN4/p27Kip1 gene to human chromosome 12p12.3.
    Author: Martin E, Cacheux V, Cavé H, Lapierre JM, Le Paslier D, Grandchamp B.
    Journal: Hum Genet; 1995 Dec; 96(6):668-70. PubMed ID: 8522324.
    Abstract:
    CDKN4/p27Kip1 is a cyclin-dependent kinase (Cdk) inhibitor implicated in G1 phase arrest, which negatively regulates G1 phase progression in response to TGF beta, and might represent a tumor suppressor gene. We report here the chromosomal assignment of the human CDKN4 gene to chromosome 12p12.3 in close proximity to highly polymorphic microsatellite markers.
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