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  • Title: An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor.
    Author: Hedley ML, Amrein H, Maniatis T.
    Journal: Proc Natl Acad Sci U S A; 1995 Dec 05; 92(25):11524-8. PubMed ID: 8524796.
    Abstract:
    We have identified an amino acid sequence in the Drosophila Transformer (Tra) protein that is capable of directing a heterologous protein to nuclear speckles, regions of the nucleus previously shown to contain high concentrations of spliceosomal small nuclear RNAs and splicing factors. This sequence contains a nucleoplasmin-like bipartite nuclear localization signal (NLS) and a repeating arginine/serine (RS) dipeptide sequence adjacent to a short stretch of basic amino acids. Sequence comparisons from a number of other splicing factors that colocalize to nuclear speckles reveal the presence of one or more copies of this motif. We propose a two-step subnuclear localization mechanism for splicing factors. The first step is transport across the nuclear envelope via the nucleoplasmin-like NLS, while the second step is association with components in the speckled domain via the RS dipeptide sequence.
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