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  • Title: Clozapine-induced agranulocytosis: a situation report up to August 1976.
    Author: Anderman B, Griffith RW.
    Journal: Eur J Clin Pharmacol; 1977 Mar 11; 11(3):199-201. PubMed ID: 852497.
    Abstract:
    The frequency of agranulocytosis in association with clozapine therapy has been estimated and compared with data reported for phenothiazine-induced agranulocytosis. Apart from the "epidemic" in Finland, where the frequency was 21 times that in other countries, there is no evidence that clozapine-related agranulocytosis is more common than the phenothiazine-related disorder. Furthermore, results are given to show that strict adherence to precautionary measure (e.g. weekly blood counts) reduces the mortality-rate of this condition.
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